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- Multidrug-Resistant Organisms Drug AGM-290
- AGM-290, an Multidrug-Resistant Organisms drug, has broad antimicrobial activity against Gram-negative bacteria, Gram-positive bacteria, and Multi-drug resistant bacteria as a disruption mechanism of bacterial cell membranes.
AGM-290 which is targeting with cell membranes has effective antimicrobial activity.
The molecular mechanism of AGM-290 can induce no antimicrobial resistance of bacteria.
| MIC (μM) | ||||||
|---|---|---|---|---|---|---|
| Sample |
E
MREF (E. faecalis) |
S
MRSA (S. aureus) |
K
MRKP (K. pnewnonia) |
A
MRAB (A. baumannii) |
P
MRPA (P. aeruginosa) |
E
MREA (E. aerogenes) |
| AGM-290 | 0.63 | 0.63 | 1.25 | 0.63 | 1.25 | 1.25 |
| AGM-291 | 0.63 | 0.63 | 1.25 | 0.63 | 2.5 | 1.25 |
| AGM-292 | 1.25 | 1.25 | >5 | 1.25 | 5 | 5 |
| Colistin | >5 | >5 | 0.63 | 0.63 | 1.25 | >5 |
| Daptomycin | 1.25 | 1.25 | >5 | >5 | >5 | >5 |
| Melittin | 2.5 | 1.25 | >5 | 2.5 | >5 | >5 |